Furin cleavage of the SARS-CoV-2 spike is modulated by O -glycosylation
SARS-COV-2 스파이크의 푸린 절단은 O- 글리코 실화에 의해 조절된다.
407
Published on
Journal: Proceedings of the National Academy of Sciences of
[Category] Biochemistry, COVID-19, SARS,
Journal: Proceedings of the National Academy of Sciences of
[Category] Biochemistry, COVID-19, SARS,
[키워드] O -
abrogate
Alpha
alpha and delta variants
Amino acid
amino acids
cells
circumvent
cleavage
coronavirus
decrease
delta variant
Delta variants
dependent on
expressed
family members
furin
furin cleavage
furin cleavage of S
furin cleavage site
GALNT
GALNT enzyme
global pandemic
glycosylating S
glycosylation
highlight
host O -glycosylation
host-mediated O -glycosylation
human respiratory cell
human respiratory cells
increase
insertion
insertion site
modulated
modulating
Mutation
O -glycosylation
P681
P681 mutation
P681 mutations
position
position 681
proline
pseudoviral infectivity
respiratory
responsible
resulting
SARS-CoV-2 coronavirus
SARS-COV-2 infection
shown
Significance
spike
Spike protein
syncytia formation
target
targets
the SARS-CoV-2
the spike protein
tropism
unique
Viral
viral infectivity
viral infectivity/tropism
[DOI] 10.1073/pnas.2109905118 PMC 바로가기 [Article Type] 407
[DOI] 10.1073/pnas.2109905118 PMC 바로가기 [Article Type] 407